What is Chromosome 21?

Down syndrome (DS) is a condition in which extra genetic material causes delays in the way a child develops, and often leads to mental retardation. It affects 1 in every 800 babies born. The symptoms of Down syndrome can vary widely from child to child. While some kids with DS need a lot of medical attention, others lead very healthy and independent lives. Though Down syndrome can't be prevented, it can be detected before a child is born. The health problems that can go along with DS can be treated, and there are many resources within communities to help kids and their families who are living with the condition. Normally, at the time of conception a baby inherits genetic information from its parents in the form of 46 chromosomes: 23 from the mother and 23 from the father. In most cases of Down syndrome, however, a child gets an extra chromosome – for a total of 47 chromosomes instead of 46. It's this extra genetic material that causes the physical and cognitive delays associated with DS. Although no one knows for sure why DS occurs and there's no way to prevent the chromosomal error that causes it, scientists do know that women age 35 and older have a significantly higher risk of having a child with the condition. At age 30, for example, a woman has less than a 1 in 1,000 chance of conceiving a child with DS. Those odds increase to 1 in 400 by age 35. By 42, it jumps to about 1 in 60. How Does Down Syndrome Affect a Child? Kids with Down syndrome tend to share certain physical features such as a flat facial profile, an upward slant to the eyes, small ears, a single crease across the center of the palms, and an enlarged tongue. A doctor can usually tell if a newborn has the condition through a physical exam. Low muscle tone and loose joints are also characteristic of children with DS, and babies in particular may seem especially â€Å"floppy. Though this can and often does improve over time, most children with DS typically reach developmental milestones – like sitting up, crawling, and walking – later than other kids. At birth, kids with DS are usually of average size, but they tend to grow at a slower rate and remain smaller than their peers. For infants, low muscle tone may con tribute to sucking and feeding problems, as well as constipation and other digestive issues. In toddlers and older children, there may be delays in speech and self-care skills like feeding, dressing, and toilet teaching. Down syndrome affects kids' cognitive abilities in different ways, but most have mild to moderate mental retardation. Kids with DS can and do learn, and are capable of developing skills throughout their lives. They simply reach goals at a different pace – which is why it's important not to compare a child with DS with typically developing siblings or even other children with the condition. Kids with DS have a wide range of abilities, and there's no way to tell at birth what they will be capable of as they grow up. Medical Problems Associated with Down Syndrome. While some kids with DS have no other health problems, others may experience a host of medical issues that require extra care. For example, half of all children born with DS also have congenital heart defects and are prone to developing pulmonary hypertension (high blood pressure in the lungs). A pediatric cardiologist can monitor these types of problems, many of which can be treated with medication or surgery. Approximately half of all kids with DS also have problems with hearing and vision. Hearing loss can be related to fluid buildup in the inner ear or to structural problems of the ear itself. Vision problems commonly include amblyopia (lazy eye), near- or farsightedness, and an increased risk of cataracts. Regular evaluations by an audiologist and an ophthalmologist are necessary to detect and correct any problems before they affect a child's language and learning skills. Other medical conditions that may occur more frequently in children with DS include thyroid problems, intestinal abnormalities, seizure disorders, respiratory problems, obesity, an increased susceptibility to infection, and a higher risk of childhood leukemia. Fortunately, many of these conditions are treatable. What is Chromosome 21? According to wikipedia. org, Chromosome 21 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. The trisomy of the 21 causes Down Syndrome. Chromosome 21 is the smallest human chromosome, spanning almost 47 million nucleotides (the building material of DNA) and representing about 1. 5 percent of the total DNA in cells. The Human Genome Project announced that they had determined the sequence of base pairs that make up this chromosome. Chromosome 21 was the second human chromosome to be fully sequenced. Chromosome 21 likely contains between 200 and 400 genes. These include: †¢ APP: amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) †¢ CBS: cystathionine-beta-synthase †¢ CLDN14: claudin 14 †¢ HLCS: holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase) †¢ KCNE1: potassium voltage-gated channel, Isk-related family, member 1 †¢ KCNE2: potassium voltage-gated channel, Isk-related family, member 2 †¢ LAD: leukocyte adhesion deficiency (symbols are ITGB2, CD18, LCAMB) †¢ SOD1: superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) †¢ TMPRSS3: transmembrane protease, serine 3. Effects of Chromosome 21 The effects of chromosome 21 is best felt by the conditions that are associated with its lack or mutation. These include: Cancer Rearrangements (translocations) of genetic material between chromosome 21 and other chromosomes have been associated with several types of cancer. For example, acute lymphoblastic leukemia (a type of blood cancer most often diagnosed in childhood) has been associated with a translocation between chromosomes 12 and 21. Another form of leukemia, acute myeloid leukemia, has been associated with a translocation between chromosomes 8 and 21. Down Syndrome In a small percentage of cases, Down syndrome is caused by a rearrangement of chromosomal material between chromosome 21 and another chromosome. As a result, a person has the usual two copies of chromosome 21, plus extra material from chromosome 21 attached to another chromosome. These cases are called translocation Down syndrome. Researchers believe that extra copies of genes on chromosome 21 disrupt the course of normal development, causing the characteristic features of Down syndrome and the increased risk of medical problems associated with this disorder. Mental Retardation Other changes in the number or structure of chromosome 21 can have a variety of effects, including mental retardation, delayed development, and characteristic facial features. In some cases, the signs and symptoms are similar to those of Down syndrome. Changes to chromosome 21 include a missing segment of the chromosome in each cell (partial monosomy 21) and a circular structure called ring chromosome 21. A ring chromosome occurs when both ends of a broken chromosome are reunited. Alzheimer’s Disease. Duplication in Amyloid precursor protein (APP) locus (duplicated segment varies in length but includes APP) on Chromosome 21 was found to cause early onset familial Alzheimer's disease (AD) in a french family set (Rovelet-Lecrux et al) and a dutch family set (Sleegers et al). Compared to AD caused by missense mutations in APP, the frequency of the AD caused by APP duplications is significant. ALL the patients that have an extra copy of APP gene due to the locus duplication show AD with severe Cerebral amyloid angiopathy (CAA).

Global Warming Position Paper Research Paper Example

Global Warming Position Paper Research Paper Example Global Warming Position Paper Paper Global Warming Position Paper Paper Essay Topic: Global Warming Studies do indeed show that our planet is getting warmer, but is this due to global warming entirely? Our great scientists in our country have been acquiring data for many years now, but the vote that global warming is a major epidemic is not unanimous. In fact many scientists argue strongly against the idea, and provide their own logical explanations on why our world is warming. With the two different sides of this growing proposed problem in our society today, how is one common citizen supposed to choose what they believe? No matter the amount of information provided, or how serious the matter will be, humans by general understanding will create and form their own opinions based upon what they want and choose to believe. Global warming is attempted to be solved and thoroughly figured out by hundreds of different scientists all over the world. These men and women are entrusted with providing the population with solid facts to show whether or not the world is warming at an alarming rate or if it is not. The most common answer heard over our nation, would be that global warming does indeed exist due to us humans, and the constant gases we emit into our atmosphere. : Between factories, pollution, cars, etc. This is something that would be easily rover to be true whether in a science lab or by an everyday person. These gases are said to have a deteriorating effect on our atmosphere, allowing heat to be trapped, and not released when the sun is no longer present. This is also referred to as the greenhouse effect. For a green house lets light in when it is Sunday with its transparent roof and sides, it traps the warmth that was given from the sun inside so the proper plants and so on could grow and mature properly. While the greenhouse effect, is speculated between different experts, it is believed to contribute a slight rise in temperature. Although the rise is not substantial, it does raise concern for our future generations on the earth. Going against the global warming idea is not as popular as going with the idea. In fact, popularity is what gives global warming a key right into our population, and enforces the idea to be a serious issue. After AY Gore came out with his movie, An Inconvenient Truth, an uproar started for Gore was recently is the election race for president. When the public sees a popular face on television, and hears and sees them all over the media, one can only expect to agree with what is in concern. For it is not their job to question or a sensible thing to do when they are not a global warming expert, quite honestly, research has shown that no one can really dub themselves as a Global Warming Expert. Current research has shown one idea that does help falsify the idea of manmade global warming. As stated before, the greenhouse effect explains the trapped gases that we emit into our atmosphere. Now one of these gases is Carbon Dioxide, or in shorter terms ICC. It has been said by Global Warming activists claim that carbon levels in our atmosphere contribute to the heating up of our planet. Right now in America, our Carbon Dioxide levels are at an all time high. This is due mostly to the burning of fossil fuels, coal being the largest. Now its simple to understand that if Carbon levels are high, temperature will also be high then. This information does not match up throughout history. After thorough research, it is shown that the carbon levels on our earth did not go on the rise until after the temperature Was on an increase. Meanings that the relationship between the two would not be significant or at least not as much as some claim them to be. Another supporting fact of this idea is the Medieval Warm Period. This period of time was hundreds of years ago, where the temperature was recorded to be one of the highest on record. Now during this time the average temperature measured more than three degrees higher than it is today. But going back to the Carbon Dioxide idea, how is this possible. Obviously hundreds of years ago, factories did not exist, fossil fuels were not being burned, and the population level was not even close to what it is now. So the carbon levels were almost nonexistent, so this poses the question of why was there a major rise in temperature. Another era which did not match the idea was during the early sasss it began. During this time, large ICC emissions began because of massive industrialization and a large amount of factories. The ICC levels were sky rocketing and set record heights. Although, temperatures were on the decline. The temperature was on the steady decline for almost four decades after that. Obviously the Carbon level affecting the temperature idea is a little off or not fully proven. Another idea that is not publicized as much as personally believe it should be is the idea of constant climate changing throughout the earths existence. It is understandable to say that this is a very vague and bold statement to make, but when looked more in to depth, it makes sense. Scientists have proven that we have had multiple ice gags, occur on our earth throughout time. There is no proven, definitive reason on why this happened. So my question is, if the earth can reach temperatures that are frigid enough to lay sheets Of ice over the majority Of the earth, the temperature must have warmed up somehow for the ice to melt and reach the climate we have today. But if there were no population, no factories, barely if any Carbon Dioxide levels, how did this happen? The idea of constant clime change needs to be taken more in to favor. Blaming the population on our climate change could be a wrong statement, climate change could be very natural, and we could possibly see a decrease in temperature in the near future that would stun the world, but anything is possible. While respect the scientists who research and strive to make our world a safer place, I respectfully disagree with the idea of global warming. Not in all its entirety, just for the fact that many believe that is all due to the cause of man. I believe in the natural cause of climate change, and believe the world is hanging little by little every single day. There is so much history of our planet that we dont know, and probably never will now about. The lack of definite facts also makes me question. If a climate change occurred plenty of times throughout history, why is the most modern one causing an uproar? The global warming epidemic caused a huge amount of concern and has created many companies, foundations, etc. To try to collect profit to support global warming research and studies. Thus, one could argue that global warming could be money making hoax, an inflated problem brought to the public to et money out of our pockets. But that is also just a theory that cannot be proven. Over time more questions will be answered, and our advancement of technology will provide more answers that will help these debatable topics. Do not mean to offend those who do believe in global warming, and I myself am not even sure what I truly believe, but what I do believe is that each person is entitled to their own opinion, and owe it to themselves to take the time to actually research global warming and decide what it is that they believe, instead of going along with the general population.

20 Exploratory Essay Topics Interesting Facts about Personal Names

20 Exploratory Essay Topics Interesting Facts about Personal Names Welcome to our second guide where we discuss 20 topics for an exploratory essay on â€Å"what’s in a name†. If you’ve missed our first guide where we discussed 10 facts for an exploratory essay on â€Å"what’s in a name† then we recommend that you go through that first before going through this one. In this guide, you’ll be introduced to 20 Topics relevant to your assignment, so you can begin writing without having to worry about where to start. We’ve also included a sample exploratory essay by choosing one of the 20 topics outlined below to give you a good idea about how an exploratory essay is faithfully written. Having essay examples on â€Å"what’s in a name† will prove to be very helpful as it will assist you tremendously in writing your essay. Once you’re done reading this guide, we highly recommend taking a look at our final and third guide, â€Å"how to write a deep exploratory essay on what’s in a name†. This last guide is perfect for polishing your writing skills and getting to know how a remarkable exploratory essay is written. Without further ado, here are 20 topics for an exploratory essay on what’s in a name: Why Personal Names Are of Psychological Significance The Relationship between Personal Names and Human Psychology Do Names Affect Your Life Significantly? Studies and Experiments Suggest They Do Why Deeper Research and Studies into Names Have Been Largely Neglected by Psychologists What Kind of Roles Does a Name Play in Your Life? The Reason Behind Trusting a Person Whose Name is Easy to Pronounce Why Boys with Feminine Names are More Likely to Bully in School Evidence Suggests Women with Masculine Names are More Attractive Physically Does Culture, Religion or Fashion Influence How We Name Our Children? Studies Show that You Cannot Have a Unique Name German Researchers Reveal the Most Appealing Names on Online Dating Platforms Why Psychologists Should Devote Their Time to Researching the Significance and Importance of Names Is there a Relationship between Names and Facial Appearance? The Effect of Names on Your Job and Professional Life How People Perceive You When You Have a Jewish or Muslim Name Psychological Factors that Affect Preferences for First Names Evidence Suggests that Your Name Might Make You a Future Smoker The Effect of Names on an Individual’s Self-Esteem and How They Seem to Feel Depressed The Definition of Attractive and Unattractive Names According to Psychologists Why Parents Should Be Careful When Choosing Their Children’s Names Liked the topics? There’s just so many to choose from, you may not know where to start. Allow us to help you with that: when choosing a topic, shortlist the ones which can be researched easily. This will assist you to writing the perfect exploratory essay without having to worry about what topic to choose. Below, we’ve written a sample exploratory essay for you on one of these 20 topics so you can have an idea about how to write an exploratory essay on your own. It’s good to take a peek or two when you are writing just to make sure you are doing it right. Anyhow, here is the exploratory essay: Sample Exploratory Essay: Do Names Affect Your Life Significantly? Studies and Experiments Suggest They Do According to Shakespeare, names are unimportant and arbitrary but research and evidence has shown otherwise, since a number of psychologists have taken a keen interest in exploring the significance of names and their effect on our lives as well as our interests. Studies now suggest that people’s lives are indeed influenced by their first names. Researchers have now found how people’s names affect their lives. For example, women that have a masculine name tend to achieve greater success in the legal profession while women with attractive names are considered more physically attractive. On the other hand, when research was conducted on boys[4]   that had feminine first names, it was concluded that they were more mischievous misbehaving at school and even after school. Although the reason was unclear, many psychologists agree that this was due to lower self-esteem and because their classmates might be embarrassing them by calling out their names. However, to this day, the real reason has not been unearthed. Our names also affect how others perceive us. During the studies, researchers found out that a name’s ethnicity plays a significant role in how we choose our jobs, our hometown and the people we interact with. In a recent study conducted by UC Irvine, it was concluded that easy to pronounce names are more truthful and trustworthy in the eyes of strangers, while people with hard to pronounce names are â€Å"hard† to trust. The study showed that easily pronounced names are also easily remembered, which is why our brain signals our instinct to trust that person. A study conducted by German researchers, found something of significance about the names. These researchers sent 47,000 emails to online daters and found out that people tend to go for attractive names. The best part? These emails did not include photos, but only names and a general introduction. This goes to show how important it is to choose an attractive name instead of a random one. For example, Alexander is one of the best names for males while for females, Charlotte is considered a top choice. These experiments and studies concluded that there is much to be revealed about names than meets the eye. Although psychologists neglect to investigate this matter further, it’s about time they started taking an interest in names and their effect on human behavior. Many studies and experiments have shown that names play an important role in our lives. Conducting more experiments and studies on a large scale would contribute a lot to what’s in a name and the significance of this subject. Now, let’s head to our final guide on how to write a deep exploratory essay on what’s in a name which rounds off our bare essentials for writing a marvelous exploratory essay. References: Robin S. S. Kramer, Alex L. Jones, (2015) Do People’s First Names Match Their Faces? Journal of Articles in Support of the Null Hypothesis Vol. 12, No. 1  jasnh.com/pdf/Vol12-No1-article1.pdf Kenneth M. Steele, Laura E. Smithwick, (1989) First Names and First Impressions: A Fragile Relationship, Sex Roles, Vol. 21, Nos. â…ž , Mars Hill College  http://www1.appstate.edu/~kms/documents/SteeleSmithwick1989.pdf Jochen E. Gebauer, Mark R. Leary, Wiebke Neberich; (2011) Unfortunate First Names Effects of Name-Based Relational Devaluation and Interpersonal Neglect, Sage Journals  http://spp.sagepub.com/content/3/5/590.short Andrew M. Colman, David J. Hargreaves, WladySlaw Sluckin; (1980) Psychological Factors Affecting Preferences for First Names* ARG, University of Leicester  https://www2.le.ac.uk/departments/npb/people/amc/articles-pdfs/psycfact.pdf Andrew M. Colman, David J. Hargreaves, WladySlaw Sluckin; (1983) The Attractiveness of Names Human Relations, Volume 36, Number 4, pp. 393-402  https://www2.le.ac.uk/departments/npb/people/amc/articles-pdfs/psycfact.pdf Hewitt, E.A. (no date) ‘WHAT’S IN A NAME: Gender, power, and Classic Maya women rulers’, Ancient Mesoamerica, 10(2), pp. 251–262. David N. Figlio, (2005) Boys Named Sue: Disruptive Children and their Peers NBER Working Paper No. 11277  nber.org/papers/w11277

Innovation of ... (e.g. e-commerce, web-based financial srvice, Research Paper

Innovation of ... (e.g. e-commerce, web-based financial srvice, paperless office, or ...) - Research Paper Example Special cases are presented on Business to Consumer markets to show its growing popularity from the consumers’ side. Website companies are cited which owing to web interface technology is increasing its revenues and customer base. In total, the paper analyses the innovation of electronic commerce technology from different angles to show its growing impact on the world economy. Advancements made in technological, social and organizational fields helped in expanding the horizon of electronic commerce to enter the realm of web-internet in the spring of 1993. Prior to this event electronic commerce depended on telecommunication technology as its medium of trade. Organizational and Social activities have become dependent on electronic commerce owing to its web-interface. In this connection, the ambit of electronic commerce now covers a broad range of activities in the fields of commerce, collaboration, communication, connection and computation. Electronic Commerce functioning along these varied fields have opened opportunities in innovation of the same. Opportunities identified along the business and social spheres include addressing larger markets, enlarging the scope of collaboration with business partners globally, transformation of business processes and working on the development to make electronic communication much faster. (Zwass, 2003) In this context Stratum Media, an electronic commerce technology developer in United Kingdom announced on the development of â€Å"Eros† technology, which an online vendor of Consumer Electronics and Home Appliances is using to promote its products. (Hollander, 1999) Further observation states that the internet web earns its success in becoming a global infrastructure for electronic commerce activities. The internet web acts as a link between the technology and innovation interface and business organizations. Internet web works towards being a global model for sharing of

Current Social Worker Law in the USA Research Paper

Current Social Worker Law in the USA - Research Paper Example Abstinence from saying anything cannot be construed as permission for participating in research. Therefore, it becomes necessary for valid and categorical consent. So, under Title 45, Section 46. 402; it is believed that for the purpose of this section, â€Å"Guardian means an individual who is authorized under applicable State or local law to consent on behalf of a child to general medical care.† (Public welfare, 2010, para.6). The main implications of this law are that children should not be forcibly made focused in research studies without their knowledge or consent. Since most young people themselves are not aware of the complexities and rigors of research studies, the consent of their parents/guardians is needed before their services. They are utilized for research studies of any kind. It is believed that the Heath and Human Services must approve and /or provide funds for research which are inline with the recommendations and directives of the Institutional Review Board (IRB) and also complies with the provisions found in Title 45, Section 46; Subsections 409. It is believed that the consistent and robust resources that are available are in terms of IRB approval for determination of IRB that research has been reviewed and may be carried out at an institution according to the directives and policies of the IRB as the governing body, whose instructions need to be carried out. Besides, it is the IRB that m ust assume major responsibility for ensuring the enforcement of rights and privileges available to children under various sub provisions of Title 45, Section 46.

Introduction to East Asian Cinema Essay Example | Topics and Well Written Essays - 1500 words

Introduction to East Asian Cinema - Essay Example The movie had a well structured thematic direction and representation of Chinese culture that it gained government’s approval. Despite application of modern settings within the film, it possesses some close similarities with ‘Journey to the West’, which was released in February 2013 by Chinese Huayi Brother’s film company. Yoo (2012) says that with respect to the moral story behind Jia’s film, one can develop an understanding that the director strives to create a contrast between two different cultures. In this regard, one can say that Jai’s film, ‘The World’, portrays a theme of clash of civilization witnessed in modern globalized societies. ‘Journey to the West’ resembles ‘The World’ in key elements constituting its thematic structure. The movie features the struggle between Chu, and Huen in an effort to retrieve lost treasures stolen by a western insurgent group. This film employs a traditional Chinese setting in its physical portrayal of scenery background. The film’s director develops a fantasy-action film creating a contrast between western extremists and traditional Chinese fighters. Ciecko (2010) says that unlike Jia’s film, ‘Journey to the West’ incorporates significant use of imagery and classical dialog in enhancing development of an fantasy filled movie, with typical crew members representing traditional Chinese art. On the contrary, Jia adopts local actors to play defined roles in showing interactions between Western world and Chinese cultures. Therefore, there is a pronounced similarity between thematic construction of ‘The World’ and that of ‘Journey to the West’. ... ‘Journey to the West’ entails depiction of Chu demonstrating his martial art skills in elaborately traditional Chinese stages. In this movie, cultural designs remain conspicuous in the attire and infrastructural development of Kung-fu stages used in fights. In addition, Huen demonstrates his exceptional ability to blend tragedy and comedy into the movie. In this context, ‘Journey to the West’ film contains some similarities with one of the East Asian movie watched in class. The movie, ‘The World’, captures most of its key scenes within Beijing’s World Park. This park lies squarely inside China’s mainland. Despite this fact, infrastructure development inside the park seeks to create an environment different from that of actual Chinese environment. The main aim of the unique constructions inside the park is meant to create an environment, where tourists would be able to view representation of the world inside a single tourist attract ion site. Ciecko (2010) says that the park’s entrance bares structures resembling typical Roman castles and Gothic sculptures. In addition, gardens inside the left side of the main entrance depict symbolic Italian landscape in terms of terrain and the grand staircase. Apart from these features at the entrance, the world’s perception in enhanced by presence of typical landmark features located in different nations around the globe. Within the movie, ‘Journey to the West’, one main actor named Xuan Zang seems to develop significant interest in the structural and physical appearances of infrastructure within the extremists warehouse facility. Commander Steward, the leader of the extremist group runs into Xuan admiring the city view from

Learning Team Assignment Analyzing and Interpreting Essay Example for Free

Learning Team Assignment Analyzing and Interpreting Essay Ask your instructor for specific information regarding the analysis you are required to perform for your data set. Combine your Week Two Learning Team assignment and Week Three findings with Week Five findings and make a recommendation to the research problem. Use the statistical tables given in the appendices of the textbook and a statistical analysis application: a Microsoft Deadline: ( ), Business General Business Its important to get familiar with the teachers you have when you start your classes. Be sure you know where they have their offices and understand how to get in touch with them easily. You need a good relationship with your professors for many reasons.